Acne Treatment with Adapalene
This acne medication
is chemically related to Vitamin-A, which belongs to a family
of compounds known as Retinoids. The action of Adapalene on
the skin is similar to Tretinoin. It promotes the peeling
of the skin and renewal of skin cells at a faster rate. Adapalene
is less irritating than Tretinoin (Retinoic Acid). This anti-acne
product also has some mild anti-inflammatory action and can
be used together with benzoyl peroxide. Other retinoids like
Tretinoin cannot be used with benzoyl peroxide because it
becomes too irritating on the skin.
and Side Effects:
not use adapalene without consulting your doctor if you are
pregnant or could become pregnant during acne treatment. This
acne medication is not intended to be used on children.
Dryness, redness and mild peeling of the skin.
gel 0.1% applied once daily was significantly more effective
in reducing acne lesions and was better tolerated than tretinoin
gel 0.025% in the treatment of acne vulgaris.
(Source: A comparison of the efficacy and safety of adapalene
gel 0.1% and tretinoin gel 0.025% in the treatment of acne
vulgaris: a multicenter trial.1: J Am Acad Dermatol. 1996
study showed that a majority of patients preferred adapalene
0.1% gel over tretinoin 0.025% cream and that it caused significantly
less skin irritation.
(Source: Adapalene 0.1% gel for the treatment of acne vulgaris:
its superiority compared to tretinoin 0.025% cream in skin
tolerance and patient preference.1: Br J Dermatol. 1998 Oct;139
Adapalene is topically applied on the skin. This anti-acne
product is available in cream or gel form at 0.1% to 0.3%
(Brand Names: Differin®, Adaferin® )
Reviews and Comments:
“Adapalene is milder on the skin but I would have to
say that Tretinoin microspheres works better for me”
1. http://www.differin.com ( 2007 Galderma Laboratories, L.P.)
2. http://www.fda.gov/cder/foi/label/2000/20748lbl.pdf ( Pharmacokinetics
of Adapalene )
( FDA Approves Differin® (adapalene) Gel, 0.3% 4. For
Acne Fast, Powerful Efficacy For Challenging Acne ( June 20,
5. Adapalene-Benzoyl Peroxide Combination Effective and Safe
for Acne CME News Author: David Douglas CME Author: Hien T.
Nghiem, MD November 9, 2007
updated: May 18, 2008